Stenabolic, known by its research name SR-9009, was developed by Professor Thomas Burris at The Scripps Research Institute. SR-9009 has been a subject of interest among medical researchers for its prospective applications in managing metabolic syndromes, enhancing endurance, and contributing to weight loss. This drug is a synthetic molecule that modulates REV-ERB proteins.
REV-ERBs are nuclear receptors, and they are found in various tissues throughout the body. These receptors are particularly prevalent in metabolic tissues such as the liver, adipose tissue (fat cells), and muscle. The distribution of REVERBs in these tissues underscores their role in regulating metabolic processes. SR-9009 modulates the action of these receptors, leading to the desired outcome of enhancing performance.
This mode of action means that SR-9009 is not a SARM. Despite being used along with SARMs, it does not affect the Androgen Receptors.
Forum users adding Stenabolic to their cutting cycles report the following positive effects:
- Bodyfat loss
- Increase in the metabolic rate
- Increase in Endurance
- Decrease of inflammation
- Decrease in bad cholesterol
Mechanism of Action
Targeting REV-ERBs, it functions by modulating REV-ERB proteins (REV-ERBα and REV-ERBβ), which play a pivotal role in regulating the expression of genes implicated in lipid and glucose metabolism, thereby influencing circadian rhythms and metabolic output.
Therapeutic and Performance Applications
Metabolic Enhancement: Early research indicates a potential to modulate metabolic activities, impacting factors like glucose metabolism and lipid storage.[10]
Endurance Improvement: Animal studies have suggested an ability to enhance endurance levels.[11]
Circadian Rhythm Modulation: Its interaction with REVERBs, which are critical in maintaining circadian rhythm, positively influences sleep and wakefulness patterns.
Dosages: Anecdotally, doses range from 20-30mg per day, divided into multiple administrations due to its relatively short half-life of approximately 4 hours. Generally, we like to see 5mgs of Steanbolic every 3 hours for 4 doses, a total of 20mgs, timed mainly around training.
Side Effects and Risk Assessment: Animal studies have provided initial insights, showing SR-9009 to be safe. Anecdotally, SR-9009 is well tolerated by users and has no hormonal side effects.[12]
“I used Stenabolic a few times, but I didn’t like the frequent dosing schedule. If you compare SR-9009 to Cardarine, I would pick Cardarine just because it’s easier to use. But if combined, I find they work in synergy, with my recommended stack being 20mgs GW-501516 and 20mgs Stenabolic SR-9009. I’ve had many cardio marathons that I’ve done on GW and tSR and can speak highly of the endurance-boosting benefits.”
-Dylan Gemelli
“I have tried both, and I can tell you that I loved both just the same. Both have their advantages, and their disadvantages. In terms of athletic performance they are very similar. Cardarine has the advantage of a longer half life, so you can take it just once per day. However, it does not have the additional benefits of SR-9009, such as the lowering of blood sugar and increasing of insulin sensitivity. On the other hand, SR-9009 needs to be taken several times per day for optimal results, and many times I found that very inconvenient. It is definitely worth giving both of them a try, and seeing by yourself which one is best.
-Lev Butlerov
