Melanotan 2

Melanotan 2 (MT-2) is a synthetic cyclic heptapeptide, an analog of the alpha-melanocyte-stimulating hormone (α-MSH), known for its ability to stimulate melanogenesis. This process determines skin and hair pigmentation. Beyond its cosmetic application for skin tanning, its effects on libido and appetite suppression have been explored.


Mechanism of Action

Melanotan 2 works by mimicking the action of α-MSH, binding to melanocortin receptors in the skin and elsewhere in the body. This interaction stimulates the production of melanin, the pigment responsible for the darkening of the skin. MT-2 binds primarily to the MC1 receptor but also exhibits affinity for MC3 and MC4 receptors, which are associated with sexual arousal and appetite suppression, respectively. The increased melanin production provides a protective layer against UV radiation, potentially reducing the risk of skin damage and skin cancer from sun exposure.


Benefits and Uses

Skin Tanning: MT-2 can induce skin tanning without the need for excessive UV exposure, offering a protective mechanism against UV-related skin damage.

Enhanced Libido: This has been reported to significantly increase sexual arousal in both men and women, making it a potential treatment for sexual dysfunction.

Appetite Suppression: Some users experience reduced appetite, which can aid in weight loss efforts.

Photoprotection: By increasing melanin in the skin, MT-2 may offer enhanced protection against UV radiation, reducing the risk of sunburn and skin cancer.


Dosage and Cycle Guidelines

The typical starting dose of Melanotan 2 is around 250 mcg per day, gradually increasing to a maintenance dose of 500-1000 mcg per day, based on response and tolerance. The peptide is administered via subcutaneous injection before bedtime to minimize potential side effects.

A loading phase of 2-3 weeks is common, with continued dosing until the desired level of tanning is achieved. Afterward, users can enter a maintenance phase with less frequent dosing, often 2-3 times a week. Sun exposure or UV tanning beds are recommended 2-3 times a week during loading to initiate and enhance the tanning process.


Potential Side Effects

Nausea and Vomiting: Common during the initial phase, these side effects often diminish with continued use.

Facial Flushing: Some users experience temporary reddening of the face shortly after injection.

Increased Libido: While a benefit for some, this can be unexpected or undesirable for others.

Appetite Suppression: This might be significant for individuals not seeking weight loss.

Darkening of Moles and Freckles: Increased melanin can lead to the darkening of pre-existing skin moles, requiring monitoring for changes.

Hyperpigmentation: Rarely, uneven or blotchy tanning can occur.

Melanotan 2 offers an intriguing blend of cosmetic and potential therapeutic benefits, especially for individuals seeking a protective tan with minimal sun exposure. However, its use should be approached with caution, with side effects monitored, and ideally under the guidance of a healthcare professional.