Within the clinical and athletic communities, the utilization of injectable steroids has been an excellent way to bypass the liver toxicity associated with oral steroids. However, besides less liver toxicity, most of the other steroid side effects are still present with injectables.

Adverse Effects: A Closer Examination

While injectable steroids may circumvent some liver-related toxicities associated with oral steroids, the potential for adverse effects remains a critical consideration. The systemic impact of steroids extends beyond hepatic metabolism, implicating cardiovascular, endocrine, and psychological domains. Cardiotoxicity, manifesting as alterations in lipid profiles, blood pressure, and myocardial structure, constitutes a significant concern. Endocrine disruption, including suppression of the hypothalamic-pituitary-gonadal axis, necessitates consideration of long-term fertility and hormonal balance. Musculoskeletal injuries, such as tendon rupture, are heightened under the influence of supraphysiological muscle strength gains. Renal strain warrants vigilance, particularly in the context of pre-existing conditions or concomitant use of nephrotoxic agents. Furthermore, the risk of infectious complications, including abscess formation and transmission of blood-borne pathogens through non-sterile injection practices, presents tangible safety concerns.