Melanotan 2 (MT-2) is a synthetic cyclic heptapeptide, an analog of the alpha-melanocyte-stimulating hormone (α-MSH), known for its ability to stimulate melanogenesis. This process determines skin and hair pigmentation. Beyond its cosmetic application for skin tanning, its effects on libido and appetite suppression have been explored.
Mechanism of Action
Melanotan 2 works by mimicking the action of α-MSH, binding to melanocortin receptors in the skin and elsewhere in the body. This interaction stimulates the production of melanin, the pigment responsible for the darkening of the skin. MT-2 binds primarily to the MC1 receptor but also exhibits affinity for MC3 and MC4 receptors, which are associated with sexual arousal and appetite suppression, respectively. The increased melanin production provides a protective layer against UV radiation, potentially reducing the risk of skin damage and skin cancer from sun exposure.
Benefits and Uses
Skin Tanning: MT-2 can induce skin tanning without the need for excessive UV exposure, offering a protective mechanism against UV-related skin damage.
Enhanced Libido: This has been reported to significantly increase sexual arousal in both men and women, making it a potential treatment for sexual dysfunction.
