Cholinergics are a class of nootropics that primarily influence the cholinergic system in the brain, which is responsible for the production, release, and regulation of acetylcholine—a crucial neurotransmitter involved in numerous cognitive processes, including memory, learning, attention, and muscle control. Acetylcholine plays a key role in how we process information, form memories, and respond to stimuli, making cholinergics an essential component in any cognitive enhancement regimen aimed at improving mental performance.

Mechanism of Action

Cholinergics work by increasing the levels of acetylcholine in the brain or by enhancing the sensitivity and effectiveness of acetylcholine receptors. There are two main ways cholinergics achieve this:

Acetylcholine Precursors: These are compounds that serve as building blocks for acetylcholine. By providing the raw materials needed for acetylcholine synthesis, these precursors ensure that the brain has sufficient levels of this neurotransmitter to support cognitive functions. Alpha-GPC and Citicoline (also known as CDP-Choline) are two of the most commonly used acetylcholine precursors in nootropic stacks.

Acetylcholinesterase Inhibitors: These are compounds that serve as building blocks for acetylcholine. By providing the raw materials needed for acetylcholine synthesis, these precursors ensure that the brain has sufficient levels of this neurotransmitter to support cognitive functions. Alpha-GPC and Citicoline (also known as CDP-Choline) are two of the most commonly used acetylcholine precursors in nootropic stacks.